NTNG2 encodes netrin-G2, a membrane-anchored presynaptic cell adhesion protein critical for neuronal circuit development and synaptic organization 1. The protein promotes neurite outgrowth and is essential for proper neuronal morphology and cortical migration, as demonstrated by severe developmental defects following NTNG2 knockdown in cultured hippocampal neurons and in vivo models 2. NTNG2 functions through CaMKII signaling pathways, with mutations leading to decreased CaMKII activity and reduced excitatory postsynaptic transmission 3. Loss-of-function mutations cause a distinct neurodevelopmental disorder characterized by global developmental delay, severe intellectual disability, hypotonia, autistic features, and behavioral abnormalities 14. Homozygous frameshift variants result in Rett-like phenotypes with areflexia, demonstrating the protein's critical role in normal neurodevelopment 2. Additionally, reduced NTNG2 mRNA expression has been observed in the temporal lobe of individuals with schizophrenia and bipolar disorder, suggesting broader involvement in neuropsychiatric conditions 5. The protein's role in synaptic plasticity and NMDAR-mediated signaling may explain the autism spectrum disorder phenotypes associated with its dysfunction 4.