NUDT11 encodes a cytoplasmic nudix hydrolase enzyme that functions primarily as a diphosphoinositol polyphosphate phosphohydrolase (DIPP3), cleaving β-phosphate groups from diphosphoinositol pentakisphosphate (PP-InsP5) and suggesting a role in cellular signal transduction 1. The enzyme also hydrolyzes diadenosine polyphosphates, with diadenosine pentaphosphate (Ap5A) and hexaphosphate (Ap6A) as preferred substrates, requiring divalent cations (particularly manganese) for activity 2. NUDT11 exhibits tissue-specific expression patterns, being primarily restricted to brain tissue in contrast to its paralog NUDT10 1. The gene has been implicated in prostate cancer pathogenesis, where suppressing NUDT11 expression influences tumor-related cellular phenotypes 3. Additionally, NUDT11 serves as a tumor-associated antigen, generating autoantibodies that have been investigated as potential biomarkers for ovarian cancer detection, though with limited early detection utility beyond existing markers 45. Recent studies have also identified NUDT11 as part of prognostic gene signatures for lung squamous cell carcinoma 6. The enzyme's dual substrate specificity for both inositol polyphosphates and diadenosine polyphosphates positions it as an important regulator of cellular signaling pathways.