NUP62 encodes nucleoporin 62, an essential component of the nuclear pore complex (NPC) that regulates nucleocytoplasmic transport and cellular function 1. The protein contains an N-terminal domain involved in nucleocytoplasmic transport and a C-terminal domain that facilitates protein-protein interactions and centrosome association 1. Beyond its canonical nuclear pore function, NUP62 plays critical roles in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation, and spindle orientation 1. In stem cell biology, NUP62 alleviates senescence and promotes stemness in human dental pulp stem cells through NSD2-dependent epigenetic reprogramming, enhancing nuclear transport of transcription factor E2F1 2. The protein shows significant disease relevance in neurodegenerative disorders, particularly ALS/FTLD, where NUP62 mislocalizes to the cytoplasm and co-aggregates with TDP-43, contributing to protein insolubility and neurodegeneration 34. Nuclear import receptors like KPNB1 can rescue TDP-43 pathology by reversing aberrant phase transitions of NUP62/TDP-43 co-aggregates 5. Clinically, NUP62 expression patterns vary across cancers and correlate with prognosis, tumor immunity, and therapeutic response, suggesting potential as a biomarker for cancer diagnosis and treatment prediction 1.