NYAP1 (neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1) is a phosphoprotein that functions as a critical bridge in PI3K signaling during neuronal development and migration. NYAP1 activates PI3K and simultaneously recruits the WAVE1 complex to the immediate vicinity of PI3K, enabling coordinated actin cytoskeleton remodeling 1. Upon stimulation, NYAP1 is tyrosine phosphorylated by the Src family kinase Fyn, facilitating its interaction with PI3K p85 and downstream activation of Akt and Rac1 1. During corticogenesis, NYAP1 functions as a downstream effector of Fyn to regulate the multipolar-to-bipolar transition and morphology of migrating neurons, with phosphorylation levels being critical for proper neuronal migration 2. NYAP1 deletion impairs brain size and neurite elongation 1. In disease contexts, NYAP1 has been identified as an Alzheimer's disease-associated genetic locus with altered RNA editing and potential involvement in neuronal morphogenesis 3. Additionally, NYAP1 genetic variants associate with immune-modulating protein levels (PILRA and PILRB) in healthy adults, suggesting roles in immune-neuronal interactions relevant to AD pathophysiology 4.