PEAR1 is a platelet and endothelial cell membrane receptor that functions as a key mediator of platelet activation through ligand-induced signaling. Mechanistically, PEAR1 serves as a receptor for multiple endogenous ligands including SVEP1 (sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1), heparin, and sulfated proteoglycans 12. Upon ligand binding to its extracellular EGF-like repeats, PEAR1 undergoes phosphorylation and activates downstream PI3K/Akt/mTOR signaling cascades 12. Beyond hemostasis, PEAR1 functions as a chaperone protein that protects CD44 from degradation, and its phosphorylation at Ser891 can be induced by LOXL2 binding 3. Clinically, PEAR1 has emerged as a significant prognostic marker in acute myeloid leukemia (AML), ranking among the strongest predictors of patient survival particularly in younger patients 4. In triple-negative breast cancer (TNBC), PEAR1 Ser891 phosphorylation represents the best independent prognostic factor and correlates with metastatic potential 3. Additionally, PEAR1 polymorphisms influence platelet aggregation and may serve as prognostic markers for cardiovascular disease risk 5. Notably, PEAR1 does not appear to be a hypertension susceptibility gene in humans 6.