Based on limited published evidence, OR1E1 is an olfactory receptor family protein with established odorant receptor activity localized to the plasma membrane. It functions in signal transduction and sensory perception of smell according to GO annotations. OR1E1 was identified as downregulated in the frontal cortex of Parkinson disease patients at premotor and parkinsonian stages 1, suggesting potential extraneuronal roles beyond classical olfaction. The protein was also detected in breast cancer plasma proteomics analysis 2, though its functional significance in cancer remains unclear. Current evidence indicates OR1E1 may have novel physiologic functions in the cerebral cortex beyond traditional olfactory detection.