OR7A5 is an olfactory receptor family 7 subfamily A member 5, a G protein-coupled receptor primarily characterized as an odorant receptor 1. Beyond its classical olfactory function in the nasal epithelium, OR7A5 exhibits broader tissue distribution and biological roles. The receptor is expressed in human tongue epithelial cells 1 and on spermatozoa, where it responds to endogenous odorant compounds including 5α-androst-16-en-3-one and 4-hydroxy-2,5-dimethyl-3(2H)-furanone, mediating calcium signaling important for sperm chemotaxis 2. In cancer biology, OR7A5 has emerged as a novel biomarker with disease relevance. Pan-cancer analysis reveals elevated OR7A5 expression correlates with immune checkpoint levels and immune infiltration across multiple tumor types 3. In gliomas specifically, OR7A5 expression associates with adverse prognosis, 1p/19p co-deletion status, and wild-type IDH status 3. Functionally, OR7A5 knockdown inhibits glioma cell proliferation and suppresses lipid metabolism-related protein expression, suggesting potential therapeutic utility 3. These findings establish OR7A5 as a multifunctional receptor with implications for both reproductive physiology and oncology, representing a potential therapeutic target for glioblastoma and related malignancies.