OR2AT4 is an olfactory receptor expressed in multiple extranasal tissues including hair follicles, keratinocytes, Merkel cells, alveolar macrophages, and bronchial epithelial cells 1234. As a G-protein coupled receptor, OR2AT4 is activated by the synthetic sandalwood odorant sandalore and mediates intracellular signaling through cAMP-dependent pathways and elevation of intracellular calcium, inducing phosphorylation of MAPK1/ERK2 and p38 kinases 15. In hair follicles, OR2AT4 activation promotes hair growth by decreasing keratinocyte apoptosis and increasing production of the anagen-prolonging growth factor IGF-1 16. In skin, OR2AT4 stimulation suppresses oxidative stress-induced senescence through the CaMKKβ/AMPK/mTORC1/autophagy signaling axis and enhances wound healing and re-epithelialization 75. Beyond skin, OR2AT4 activation upregulates antimicrobial peptide expression including dermcidin in hair follicles, modulating the hair follicle microbiome composition 8. In immune cells, OR2AT4 stimulation reduces phagocytic capacity and proinflammatory cytokine release in alveolar macrophages and decreases IL-8 production in some contexts 24. These findings position OR2AT4 as a promising therapeutic target for hair loss, wound healing, aging-related skin disorders, and steroid-resistant inflammatory lung diseases.