OR2C1 is an olfactory receptor that detects organosulfur odorants with thioether groups, including (methylthio)methanetiol, acetophenone, and benzaldehyde. It functions through G protein-coupled signaling via adenylyl cyclase activation. Based on limited published evidence, OR2C1 expression may also occur outside olfactory tissues; notably, low OR2C1 expression was identified as a potential biomarker of favorable overall survival in IDH wild-type gliomas 1. The receptor may contribute to olfactory axon fasciculation and targeting.