2 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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8PubMed Papers
2Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
cognitionolfactory receptor activityplasma membranedetection of chemical stimulus involved in sensory perception of smellmetabolic syndromeage-related macular degeneration
Based on limited published evidence, OR52B4 encodes an odorant receptor localized to the plasma membrane with olfactory receptor activity. While the primary characterized function is odorant detection, genetic variants in OR52B4 have been associated with anti-VEGF therapy response in age-related macular degeneration. Specifically, rs4910623 and rs10158937 associate with poor treatment response 1, while rs323085 associates with good response 2. The mechanistic basis for these pharmacogenetic associations remains unclear.
1
SNP rs4910623 in OR52B4 associated with poor visual acuity response to anti-VEGF treatment in neovascular AMD at 3 and 6 months
PMID: 278925142
Meta-analysis confirmed rs4910623 and rs10158937 in OR52B4 associated with poor anti-VEGF response, while rs323085 associated with good response in AMD patients
PMID: 34403208⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
metabolic syndromeOpen Targets
age-related macular degenerationOpen Targets
No pathogenic variants reported on ClinVar for this gene.
No tissue expression data available for this gene.