OR52E4 is an olfactory receptor family member functioning as an odorant receptor with plasma membrane localization 12. While the provided abstracts do not detail its specific ligand or molecular mechanism, OR52E4 has emerged as a novel susceptibility locus across multiple cardiovascular and metabolic conditions. Genetic variants in OR52E4 were identified as significantly associated with early-onset coronary artery disease (CAD) in Japanese populations 1, early-onset myocardial infarction (MI) 2, metabolic syndrome 3, and subarachnoid hemorrhage (SAH) 4. Additionally, OR52E4 expression was found to be upregulated in invasive growth hormone-secreting pituitary adenomas 5 and showed altered transcriptional levels associated with comorbid psychopathology in brain and blood tissues 6. The consistent identification of OR52E4 across these diverse pathological conditions suggests potential pleiotrophic effects, though the mechanistic basis remains unclear. SNP genotyping at OR52E4 loci may have clinical utility for cardiovascular risk assessment in affected populations, though functional studies are needed to elucidate the molecular mechanisms underlying these associations.