OR52N2 is an olfactory receptor family member that functions as a G protein-coupled receptor with seven transmembrane domains 1. As a typical odorant receptor, OR52N2 localizes to ciliated receptor cells of the olfactory epithelium 1 and demonstrates ligand-binding capacity for prostaglandin E2 (PGE2), activating downstream CREB signaling pathways 1. This receptor plays a role in sex pheromone signaling, where PGE2-mediated OR52N2 activation regulates reproductive behaviors 1. Beyond olfactory function, OR52N2 expression is dysregulated in aging skin, showing differential age-related expression patterns independent of gender 2, and is aberrantly upregulated in invasive growth hormone-secreting pituitary adenomas, where it participates in competing endogenous RNA networks affecting adenoma invasiveness 3. Clinically, OR52N2 variants have been associated with oral cavity and pharyngeal cancer susceptibility, with a significant locus identified at 11p15.4 4. Additionally, OR52N2 expression is modulated by extracellular vesicle-associated miRNA networks in COVID-19 pathophysiology 5, suggesting broader roles in inflammatory disease mechanisms beyond traditional olfactory signaling.