OR52N4 is an olfactory receptor family member with odorant receptor activity, localized to the plasma membrane. Based on limited published evidence, OR52N4 was identified as a robust biomarker in depression-driven transcriptomic signatures associated with myocardial infarction and heart failure risk 1. The gene was screened through integrated multi-cohort transcriptomic analysis and incorporated into risk-score models that discriminated MI and HF in peripheral blood, though its specific mechanistic role in cardio-depressive comorbidity remains unclear.