1 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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3PubMed Papers
15Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
olfactory receptor activityplasma membraneG protein-coupled receptor signaling pathwaysensory perception of smellneurodegenerative diseasehypertensionMODYessential hypertension
Based on limited published evidence, OR5B3 is an olfactory receptor that functions as a G protein-coupled receptor involved in odorant detection and sensory perception of smell. The protein localizes to the plasma membrane and exhibits olfactory receptor activity through G protein-coupled receptor signaling pathways. A genome-wide gene-based association study identified OR5B3 as significantly associated with distal pain sensitization in osteoarthritis patients 1, though the mechanistic connection between olfactory receptor function and pain sensitization remains unclear.
1
OR5B3 was identified as the most significant gene associated with distal sensitization (pressure pain detection thresholds at pain-free sites) in knee osteoarthritis patients
PMID: 34958702⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
neurodegenerative diseaseOpen Targets
essential hypertensionOpen Targets
maturity-onset diabetes of the young type 3Open Targets
type 2 diabetes mellitusOpen Targets
essential tremorOpen Targets
mathematical abilityOpen Targets
hyperproinsulinemiaOpen Targets
maturity-onset diabetes of the young type 10Open Targets
Glycogen storage disease due to hepatic glycogen synthase deficiencyOpen Targets
glycogen storage disorder due to hepatic glycogen synthase deficiencyOpen Targets
diabetes mellitus, permanent neonatal 4Open Targets
transient neonatal diabetes mellitusOpen Targets
open-angle glaucomaOpen Targets
No pathogenic variants reported on ClinVar for this gene.