ORC6 (origin recognition complex subunit 6) is a component of the origin recognition complex (ORC) that facilitates DNA replication initiation. ORC6 functions in ATP-dependent binding to replication origins and assembly of the pre-replication complex required for loading the MCM2-7 replicative helicase double hexamer onto DNA 1. In human cells, unlike in budding yeast, ORC6 is not essential but enhances MCM loading through recruitment of ORC to the MCM dimerization interface, and human MCM loading can proceed through multiple alternative pathways independent of ORC6 12. ORC6 mutations cause Meier-Gorlin syndrome (MGS), a rare autosomal recessive primordial dwarfism disorder characterized by microtia, patellar anomalies, and growth retardation; ORC6 mutations account for approximately 67-78% of detected pre-replication complex gene mutations in MGS patients 3. Beyond its canonical replication function, elevated ORC6 expression promotes cancer cell proliferation in non-small cell lung cancer and pancreatic ductal adenocarcinoma by enhancing cell cycle progression through cyclin upregulation and p53 inhibition 45. ORC6 overexpression correlates with reduced overall survival in colorectal and lung adenocarcinoma 6, and ORC6 knockdown sensitizes colon cancer cells to chemotherapy 7.