OSBPL10 encodes oxysterol-binding protein-like 10 (ORP10), a lipid transporter that plays a crucial role in cellular lipid metabolism regulation. The protein functions as a negative regulator of lipid biosynthesis, suppressing hepatic lipogenesis and very-low-density lipoprotein production in hepatocytes 1. OSBPL10 is involved in intracellular lipid transport, likely exchanging phosphatidylserine with phosphatidylinositol 4-phosphate between cellular membranes, and associates dynamically with microtubules consistent with transport functions 1. The gene shows significant clinical relevance across multiple diseases. Genetic variants in OSBPL10 are associated with high triglyceride levels in dyslipidemic populations, suggesting a role in metabolic disorders 1. In infectious disease, lower OSBPL10 expression in individuals of African ancestry appears protective against dengue hemorrhagic fever through the LXR/RXR lipid metabolism pathway 2. The gene also demonstrates oncological significance, with elevated expression associated with poor prognosis across multiple cancer types and promotion of tumor cell proliferation and migration through VEGF/AKT signaling 3. OSBPL10 mutations are found in various hematological malignancies and correlate with hemophagocytic lymphohistiocytosis in some lymphomas 4. These findings position OSBPL10 as a potential therapeutic target for metabolic, infectious, and oncological diseases.