OSBPL11 (oxysterol binding protein like 11) functions as a lipid transport protein involved in cellular cholesterol homeostasis and metabolic regulation. The protein binds 25-hydroxycholesterol and forms heterodimers with OSBPL9 to facilitate phosphatidylserine-phosphatidylinositol-4-phosphate exchange between the endoplasmic reticulum and trans-Golgi network, which is critical for sphingomyelin synthesis 1. OSBPL11 plays regulatory roles in adipocyte differentiation and triglyceride storage 2. Recent studies suggest the protein binds vitamin D metabolites and may be involved in intracellular vitamin D transport, with genetic variants associated with vitamin D status in African populations and cardiometabolic health 3. Disease relevance includes associations with cancer progression, where OSBPL11 downregulation correlates with hepatocellular carcinoma 4 and targeting by miR-7-5p in acute myeloid leukemia through PI3K/AKT/mTOR pathway suppression 5. Additionally, OSBPL11 variants are linked to cardiovascular disease risk factors in obesity 6 and elevated expression correlates with atherosclerosis and Alzheimer's disease 7. The protein localizes to membrane contact sites and is essential for lipid homeostasis across multiple cellular compartments.