PABPC3 (poly(A) binding protein cytoplasmic 3) is a testis-specific cytoplasmic RNA-binding protein that binds poly(A) tails of mRNAs with slightly lower affinity than the ubiquitous PABPC1 1. During spermatogenesis, PABPC3 shows stage-specific expression, being detectable in pachytene spermatocytes and increasing in round spermatids 2. The protein can interact with translation-associated factors including EIF4G, PAIP1, and PAIP2, though unlike PABPC1, it is barely associated with translationally active polysomes and is enriched in chr13 bodies 2. PABPC3 expression is significantly altered in male infertility, with both mRNA and protein levels gradually decreasing from hypospermatogenesis to Sertoli cell-only syndrome in non-obstructive azoospermia patients 3. In cancer contexts, PABPC3 functions as an oncogene, promoting ovarian cancer metastasis by downregulating CLDN1 expression, with high expression correlating with shorter overall survival 4. The gene is also implicated in osteosarcoma progression and has been identified as part of stress granule-related gene signatures in ovarian cancer prognosis 56. Somatic mutations in PABPC3 have been associated with platinum resistance in epithelial ovarian carcinoma 7.