PCBP3 (poly(rC) binding protein 3) is an RNA-binding protein that preferentially binds oligodeoxycytidine sequences and localizes to the nucleus, cytoplasm, and extracellular exosomes. It regulates mRNA metabolism and transcription, with demonstrated roles in post-transcriptional gene regulation 1. PCBP3 participates in alternative splicing regulation during epithelial-mesenchymal transition in breast cancer, affecting expression of cell adhesion genes including ITGA6, ADGRE5, and TNC 1. The protein is functionally distinct from PCBP2, which serves as an iron chaperone for ferroportin 1-mediated iron export; PCBP3 does not interact with ferroportin 1 2. PCBP3 plays a crucial role in pancreatic cancer ferroptosis through direct interaction with lncRNA A2M-AS1, promoting iron metabolism-dependent cell death via p38 activation and AKT-mTOR pathway inhibition 3. Clinically, PCBP3 expression levels correlate with pancreatic cancer prognosis and tumor stage, serving as a potential biomarker for favorable outcomes 4. Additionally, PCBP3 variants are associated with diffusion capacity for carbon monoxide (DlCO) in COPD patients 5, and PCBP3 displays notable genetic variation in human populations, with differential repeat composition across superpopulations 6.