PAK5 is a serine/threonine protein kinase that functions as a critical regulator of multiple cellular processes including cytoskeleton organization, cell migration, proliferation, and survival 1. PAK5 is activated by Cdc42 and Rac1 GTPases, leading to autophosphorylation and activation of downstream signaling cascades 2. The kinase promotes cell survival through anti-apoptotic mechanisms and regulates cytoskeletal dynamics by phosphorylating substrates such as MARK2 and CTNND1 2. PAK5 is significantly dysregulated across multiple cancer types including breast cancer, cervical cancer, renal carcinoma, and melanoma 1. In HER2-positive breast cancer, PAK5 promotes trastuzumab resistance by phosphorylating METTL14 to enhance m6A modification of MALAT1 lncRNA, thereby stabilizing nuclear HER2 accumulation 3. In cervical cancer, HPV E7-mediated upregulation of ALKBH5 enhances PAK5 expression through m6A demethylation, promoting malignant phenotypes 4. PAK5 also facilitates renal cell carcinoma metastasis by phosphorylating Slug to increase N-cadherin expression 5. Additionally, PAK5 regulates anaerobic glycolysis in endometriosis through PKM2 phosphorylation at Ser519 6. These findings establish PAK5 as a therapeutic target across multiple disease contexts.