1 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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2PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLETumor Suppressor
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
regulation of protein stabilitynegative regulation of proteasomal ubiquitin-dependent protein catabolic processpositive regulation of apoptotic processnucleoluschronic pancreatitismyoclonic epilepsygenetic developmental and epileptic encephalopathyAbnormality of the skeletal system
Based on limited published evidence, PANO1 (proapoptotic nucleolar protein 1) is a nucleolar protein that functions as an apoptosis inducer and potential tumor suppressor. PANO1 enhances stability of the tumor suppressor CDKN2A/p14ARF by protecting it from proteasomal degradation, thereby increasing p14ARF protein levels 1. Overexpression of PANO1 induces apoptosis under low serum conditions in a p14ARF-dependent manner and suppresses tumorigenicity in vivo 1. PANO1 knockdown reduces p14ARF levels, indicating a regulatory relationship between these proteins.
1
PANO1 modulates p14ARF stability by protecting it from degradation, induces apoptosis in a p14ARF-dependent manner, and suppresses tumorigenicity in vivo
PMID: 22094112⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
chronic pancreatitisOpen Targets
genetic developmental and epileptic encephalopathyOpen Targets
myoclonic epilepsyOpen Targets
Abnormality of the skeletal systemOpen Targets
breast carcinomaOpen Targets
corneal dystrophyOpen Targets
Fuchs' endothelial dystrophyOpen Targets
breast cancerOpen Targets
aortic stenosisOpen Targets
aortic valve calcificationOpen Targets
Miyoshi myopathyOpen Targets
bladder transitional cell carcinomaOpen Targets
hepatocellular carcinomaOpen Targets
triple-negative breast cancerOpen Targets
No pathogenic variants reported on ClinVar for this gene.
No tissue expression data available for this gene.