Based on limited published evidence, PCDHB11 is a calcium-dependent cell-adhesion protein involved in nervous system development and neuronal synapse assembly. UniProt annotations indicate roles in cell adhesion molecule binding and chemical synaptic transmission. PCDHB11 demonstrates homophilic cell adhesion 1, making it the human-specific protocadherin with the highest number of evolutionary substitutions, though functional changes from these substitutions remain unclear. The protein is expressed on central nervous system cell surfaces. Additional transcriptomic evidence suggests altered PCDHB11 expression in melanoma chemoresistant populations 2, though the significance remains undetermined.