PCDHB13 — protocadherin beta 13

6 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

15PubMed Papers

#15,548 · top 80% of 19K genes

0Diseases

0Drugs

0Pathogenic Variants

Experimental GO EvidenceSwiss-Prot Reviewed

cell adhesion molecule bindingplasma membranecell adhesioncalcium-dependent cell-cell adhesion

AI Summary

PCDHB13 is a calcium-dependent cell-adhesion protein localized to the plasma membrane. UniProt annotations suggest involvement in neuronal connection establishment and maintenance through synapse assembly and chemical synaptic transmission. Based on limited published evidence, PCDHB13 functions in calcium-dependent cell-cell adhesion and may associate with microtubule networks 1. In non-small cell lung cancer, PCDHB13 acts as a FOSB target gene within a tumor-suppressive pathway, with downregulation correlating to advanced pathological grade 1.

Sources cited

PCDHB13 is a FOSB target gene functionally associated with microtubules; downregulation in NSCLC correlates with pathological grade; overexpression attenuates cancer growth

PMID: 30658436

⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Related Genes

No related genes found for this gene.

Tissue Expression

No tissue expression data available for this gene.

Gene Interaction Network

No interaction data available for this gene.

StructureAlphaFold

Preparing viewer…

AlphaFoldAI-predicted · UniProt Q9Y5F0

View on AlphaFold

ConstraintgnomAD v4.1

LOEUFⓘ

1.94LoF Tolerant

pLIⓘ

0.11Tolerant

Observed/Expected LoF3.27 [0.38–1.94]

Rankings2 dim

Where PCDHB13 stands among ~20K protein-coding genes

#15,650of 20,598
Most Researched15
#17,546of 17,882
Most Constrained (LOEUF)1.94