PCDHB4 — protocadherin beta 4 | GeneE

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5 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

13PubMed Papers

#16,159 · top 83% of 19K genes

0Diseases

0Drugs

0Pathogenic Variants

Experimental GO EvidenceSwiss-Prot Reviewed

cell adhesion molecule bindingcell adhesionplasma membranenervous system development

AI Summary

AI summary not yet available. Showing NCBI Gene summary.

protocadherin beta 4

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Related Genes6

PCDHB5Shared pathway100%PCDHB14Shared pathway100%PCDHB13Shared pathway100%PCDHB11Shared pathway100%PCDHB10Shared pathway100%PCDHB9Shared pathway100%

Tissue Expression

No tissue expression data available for this gene.

Gene Interaction Network6 neighbors

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StructureAlphaFold

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AlphaFoldAI-predicted · UniProt Q9Y5E5

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ConstraintgnomAD v4.1

LOEUFⓘ

1.93LoF Tolerant

pLIⓘ

0.12Tolerant

Observed/Expected LoF2.55 [0.36–1.93]

Rankings2 dim

Where PCDHB4 stands among ~20K protein-coding genes

#16,249of 20,598
Most Researched13
#17,511of 17,882
Most Constrained (LOEUF)1.93

Meta

Genes detectedPCDHB4

Sources retrieved5 papers

Response time—

Sources5

1

Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.

Genome Res · 2001

0.95

2

Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.

Genes Dev · 2000

0.95

3

Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.

Proc Natl Acad Sci U S A · 2000

0.95

4

Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.

J Mol Biol · 2000

0.95

5

A striking organization of a large family of human neural cadherin-like cell adhesion genes.

Cell · 1999

0.95

View all 13 papers on PubMed →