PEX11G (peroxisomal biogenesis factor 11 gamma) is a peroxisomal membrane protein that promotes peroxisome proliferation and division. As a member of the mammalian PEX11 protein family alongside PEX11α and PEX11β 1, PEX11G functions in membrane remodeling processes essential for peroxisomal dynamics 2. The protein promotes membrane protrusion and elongation on the peroxisomal surface, facilitating organelle fission and regulating peroxisome size 3. Mechanistically, PEX11G expression can be induced by dietary sulfur amino acids (cysteine and methionine) through TOR signaling 4. Overexpression of PEX11G increases peroxisome size and promotes inter-organelle contacts between peroxisomes and lipid droplets, linking peroxisome dynamics to lipid metabolism and fat loss 4. Regarding disease relevance, PEX11G variants have been associated with clinical phenotypes in peroxisomal disorders. A PEX11γ missense variation was identified in a mevalonate kinase deficiency patient correlating with visual blurring 5. Additionally, reduced PEX11γ expression exacerbates peroxisome division defects in patients with PEX11β mutations, expanding the genetic spectrum of peroxisomal disorders 6. PEX11G-related lncRNAs show prognostic significance in colorectal cancer by regulating ferroptosis 7, and PEX11G methylation associates with blood pressure regulation in obesity 8.