2 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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10PubMed Papers
5Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
peroxisome matrix targeting signal-2 bindingprotein bindingprotein import into peroxisome matrix, dockingcytosolinjurysmoking initiationattention deficit hyperactivity disordersubstance abuse
Based on limited published evidence, PEX39 is a cytosolic peroxin that facilitates peroxisomal protein import through the PTS2 (peroxisomal targeting signal-2) pathway. PEX39 binds PEX7 and stabilizes its interaction with PTS2-containing cargo proteins via an (R/K)PWE motif 1. After PTS2 cargo is imported, PEX39 extracts PEX7 from the peroxisomal membrane's YG phase on the cytosolic side and reloads it with new cargo to initiate subsequent import cycles 2. This handover mechanism between PEX39 and the membrane translocon PEX13 represents a novel paradigm for peroxisomal protein biogenesis.
1
PEX39 extracts PEX7 from the peroxisomal YG phase and facilitates PEX7 reloading with cargo for PTS2 import cycling
PMID: 403463492
PEX39 is a cytosolic peroxin that binds PEX7 via (R/K)PWE motif and stabilizes PEX7-cargo interaction for PTS2-containing protein import
PMID: 40739340⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
smoking initiationOpen Targets
attention deficit hyperactivity disorderOpen Targets
substance abuseOpen Targets
peroxisomal diseaseOpen Targets
No pathogenic variants reported on ClinVar for this gene.