PLEKHA7 is a cytoskeletal adaptor protein localized to the zonula adherens subdomain of epithelial adherens junctions. It stabilizes E-cadherin complexes by linking them to the minus ends of noncentrosomal microtubules via interaction with CAMSAP3 and recruitment of KIFC3 kinesin 1, and mediates docking of ADAM10 to junctions through a PDZD11-dependent interaction with TSPAN33. PLEKHA7 also functions as a Rac1/Cdc42 GTPase-activating protein, stimulating GTP hydrolysis of these small GTPases to regulate actin cytoskeleton organization and maintain epithelial barrier integrity 2. Additionally, PLEKHA7 associates with the microprocessor complex at apical junctions and regulates miRNA-mediated growth pathways 3. Genetically, PLEKHA7 variants, particularly rs11024102, show strong association with primary angle closure glaucoma (PACG) in Asian populations 4, where reduced PLEKHA7 expression correlates with disease risk alleles. PLEKHA7 is expressed in blood-aqueous barrier structures including iris epithelium, ciliary body, and trabecular meshwork 5. In gastric cancer, transcriptional repression of PLEKHA7 by the hTERT–p50 complex promotes invasion and metastasis 6, suggesting a tumor-suppressive role. Although PLEKHA7 is not required for organism viability, it fine-tunes cardiovascular physiology, glaucoma susceptibility, and epithelial morphogenesis.