PLEKHA7 is a cytoskeletal adaptor protein required for zonula adherens biogenesis and maintenance in epithelial cells 1. It stabilizes the E-cadherin complex by linking it to minus ends of noncentrosomal microtubules through interaction with CAMSAP3 and KIFC3 kinesin 2, and mediates ADAM10 docking to adherens junctions via PDZD11-dependent interaction with TSPAN33 3. PLEKHA7 comprises two WW domains, a pleckstrin-homology domain, and proline-rich and coiled-coil domains, interacting with p120-catenin, paracingulin, and afadin 4. Functionally, PLEKHA7 acts as a novel Rac1/Cdc42 GTPase-activating protein that regulates actin cytoskeleton organization and maintains tight junction permeability 5. Disease associations include primary angle closure glaucoma (PACG), where reduced PLEKHA7 expression compromises blood-aqueous barrier integrity in ciliary epithelium and trabecular meshwork 65. SNP rs11024102 in PLEKHA7 shows significant association with PACG in Asian populations 78. Additionally, downregulation of PLEKHA7 promotes gastric cancer invasion and metastasis through hTERT-p50-mediated transcriptional repression 9. PLEKHA7 is implicated in cardiovascular physiology, hypertension, and susceptibility to staphylococcal α-toxin 4.