PLP2 (proteolipid protein 2) is a membrane-associated protein that plays complex roles in cancer biology and cellular processes. In cancer contexts, PLP2 expression is significantly associated with tumor progression and patient prognosis across multiple malignancies. High PLP2 expression correlates with poor survival outcomes in glioblastoma multiforme (GBM) 1 and multiple myeloma, where it serves as a prognostic biomarker for high-risk patients 2. In cervical carcinoma, PLP2+ tumor epithelial progenitor cells represent a critical subpopulation influencing cancer differentiation and progression 3. The protein is subject to post-transcriptional regulation, as miR-664 negatively regulates PLP2 expression and promotes cell proliferation and invasion in T-cell acute lymphoblastic leukemia 4. At the molecular level, PLP2 functions as a co-chaperone in the TRiC/CCT complex-mediated folding of cytoskeletal proteins tubulin and actin, facilitating substrate stabilization and proper protein folding 5. Additionally, PLP2 appears to protect cells from DNA damage-induced apoptosis through ROS-activated mechanisms 6. The protein's involvement in immune cell infiltration and correlation with PD-L1 expression suggests potential roles in tumor immune evasion 1.