POTEF (POTE ankyrin domain family member F) is a primate-specific protein with multifaceted roles in cellular homeostasis and disease pathogenesis. Structurally, POTEF contains an actin-binding domain and interacts with the chaperonin-containing TCP-1 complex (CCT), which regulates protein folding critical for cell proliferation 1. In normal physiology, POTEF expression suppresses granulosa cell proliferation and is dynamically regulated during folliculogenesis, with dysregulation implicated in primary ovarian insufficiency and potential ovarian autoimmunity 1. In prostate cancer, POTEF is downregulated following PSA-mediated signaling, and this downregulation correlates with enhanced tumorigenesis and metastasis 2. The related lncRNA POTEF-AS1 is androgen-regulated and promotes prostate cancer progression by suppressing Toll-like receptor and apoptosis-related pathways 34. Beyond oncology, POTEF emerges as a dysregulated protein in Omicron SARS-CoV-2 infection, where it participates in coagulation cascade disruption and hemostatic dysfunction 5. POTEF also functions as a hub protein in network-based disease associations among parathyroid adenomas, cardiovascular disease, and type-2 diabetes 6, and ranks among top central genes in intervertebral disc degeneration pathways 7. These findings position POTEF as a multifunctional regulator with diagnostic and therapeutic potential across diverse pathological conditions.