POTEI (POTE ankyrin domain family member I) is a structural protein with roles in cellular architecture and potential disease associations. As an ACTB-containing chimeric gene 1, POTEI shares sequence similarity with actin-binding proteins, consistent with its annotated function in actin cytoskeleton organization and postsynaptic structural components. The gene is expressed in tissues including the inner ear 2. Clinically, POTEI has been identified as a candidate gene for non-syndromic hearing impairment based on whole-exome sequencing in Ghanaian families, though functional validation is pending 2. Additionally, POTEI emerged as a biomarker in precision oncology: it was significantly upregulated in responders to capivasertib (AKT inhibitor) in patients with AKT1 E17K-mutated tumors, suggesting potential predictive value for treatment response in specific malignancies 3. POTEI also appeared in gene expression studies of low-dose radiation responses in human coronary artery endothelial cells, indicating involvement in radiation-induced cellular responses 4. These findings suggest POTEI functions in structural cellular processes and may serve as a biomarker in both hearing impairment and oncology contexts, though further functional characterization is needed to establish definitive molecular mechanisms.