PPP1R2B — PPP1R2 family member B

5 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

19PubMed Papers

#14,555 · top 75% of 19K genes

14Diseases

top 93%

0Drugs

0Pathogenic Variants

Experimental GO EvidenceSwiss-Prot Reviewed

protein bindingprotein phosphatase inhibitor activityintracellular signal transductionregulation of signal transductioncoronary artery diseaseliver diseasealcohol drinkingimmune system disease

AI Summary

AI summary not yet available. Showing NCBI Gene summary.

PPP1R2 family member B

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations14

coronary artery diseaseOpen Targets

0.23Weak

liver diseaseOpen Targets

0.11Weak

alcohol drinkingOpen Targets

0.09Suggestive

immune system diseaseOpen Targets

0.08Suggestive

head injuryOpen Targets

0.07Suggestive

attention deficit hyperactivity disorderOpen Targets

0.06Suggestive

self-injurious ideationOpen Targets

0.04Suggestive

smoking cessationOpen Targets

0.02Suggestive

post-traumatic stress disorderOpen Targets

0.02Suggestive

delusional disorderOpen Targets

0.02Suggestive

schizophreniaOpen Targets

0.02Suggestive

dementiaOpen Targets

0.02Suggestive

diabetic ketoacidosisOpen Targets

0.02Suggestive

peripheral nervous system diseaseOpen Targets

0.02Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression6 tissues

Bone Marrow

100%

Heart

Ovary

Liver

Brain

Lung

Gene Interaction Network6 neighbors

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StructureAlphaFold

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AlphaFoldAI-predicted · UniProt Q6NXS1

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ConstraintgnomAD v4.1

LOEUFⓘ

1.57LoF Tolerant

pLIⓘ

0.00Tolerant

Observed/Expected LoF0.85 [0.48–1.57]

Rankings2 dim

Where PPP1R2B stands among ~20K protein-coding genes

#14,501of 20,598
Most Researched19
#15,514of 17,882
Most Constrained (LOEUF)1.57