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0 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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PRAMEF6
PRAME family member 6
Chromosome 1 · 1p36.21
NCBI Gene: 440561Ensembl: ENSG00000232423.6HGNC: HGNC:30583UniProt: Q5VXH4
4PubMed Papers
0Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
ubiquitin-like ligase-substrate adaptor activityproteasome-mediated ubiquitin-dependent protein catabolic processCul2-RING ubiquitin ligase complexcytoplasm
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

PRAME family member 6

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
PRAMEF27Shared pathway100%PRAMEF14Shared pathway100%PRAMEF22Shared pathway100%PRAMEF20Shared pathway100%PRAMEF19Shared pathway100%PRAMEF33Shared pathway100%
Tissue Expression

No tissue expression data available for this gene.

Gene Interaction Network
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PRAMEF6PRAMEF27PRAMEF14PRAMEF22PRAMEF20PRAMEF19PRAMEF33
PROTEIN STRUCTURE
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AlphaFoldAI-predicted · UniProt Q5VXH4
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
0.49Moderately Constrained
pLIⓘ
0.91Intolerant
Observed/Expected LoF0.00 [0.00–0.49]
RankingsWhere PRAMEF6 stands among ~20K protein-coding genes
  • #18,720of 20,598
    Most Researched4
  • #2,921of 17,882
    Most Constrained (LOEUF)0.49 · top quartile
Genes detectedPRAMEF6
Sources retrieved0 papers
Response time—