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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
PRAMEF33
PRAME family member 33
Chromosome 1 Β· 1p36.21
NCBI Gene: 645382Ensembl: ENSG00000237700.2HGNC: HGNC:49193UniProt: A0A0G2JMD5
1PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
ubiquitin-like ligase-substrate adaptor activityproteasome-mediated ubiquitin-dependent protein catabolic processcytoplasmCul2-RING ubiquitin ligase complexazoospermiapartial chromosome Y deletionspermatogenic failure 57spermatogenic failure 50
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

PRAME family member 33

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
azoospermiaOpen Targets
0.09Suggestive
partial chromosome Y deletionOpen Targets
0.09Suggestive
spermatogenic failure 57Open Targets
0.08Suggestive
spermatogenic failure 50Open Targets
0.08Suggestive
spermatogenic failure 25Open Targets
0.08Suggestive
spermatogenic failure, X-linked, 2Open Targets
0.08Suggestive
spermatogenic failure 71Open Targets
0.08Suggestive
spermatogenic failure 63Open Targets
0.08Suggestive
isochromosomy YpOpen Targets
0.08Suggestive
spermatogenic failure 61Open Targets
0.07Suggestive
spermatogenic failure 62Open Targets
0.07Suggestive
spermatogenic failure 88Open Targets
0.07Suggestive
Male infertility with spermatogenesis disorder due to single gene mutationOpen Targets
0.07Suggestive
spermatogenic failure 59Open Targets
0.07Suggestive
spermatogenic failure 60Open Targets
0.07Suggestive
spermatogenic failure 73Open Targets
0.07Suggestive
spermatogenic failure 74Open Targets
0.07Suggestive
spermatogenic failure 48Open Targets
0.07Suggestive
isochromosomy YqOpen Targets
0.07Suggestive
spermatogenic failure 84Open Targets
0.07Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
PRAMEF1Shared pathway100%PRAMEF2Shared pathway100%PRAMEF5Shared pathway100%PRAMEF9Shared pathway100%PRAMEF10Shared pathway100%PRAMEF12Shared pathway100%
Tissue Expression6 tissues
Liver
100%
Lung
0%
Bone Marrow
0%
Ovary
0%
Heart
0%
Brain
0%
Gene Interaction Network
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PRAMEF33PRAMEF1PRAMEF2PRAMEF5PRAMEF9PRAMEF10PRAMEF12
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt A0A0G2JMD5
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.53LoF Tolerant
pLIβ“˜
0.05Tolerant
Observed/Expected LoF0.69 [0.34–1.53]
RankingsWhere PRAMEF33 stands among ~20K protein-coding genes
  • #19,388of 20,598
    Most Researched1
  • #15,350of 17,882
    Most Constrained (LOEUF)1.53
Genes detectedPRAMEF33
Sources retrieved0 papers
Response timeβ€”