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26 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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PRC1
protein regulator of cytokinesis 1
Chromosome 15 · 15q26.1
NCBI Gene: 9055Ensembl: ENSG00000198901.15HGNC: HGNC:9341UniProt: O43663
178PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Hub GeneOncogene
RESEARCH IMPACT
Trending
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingmidbodynucleusnucleoplasmneurodegenerative diseasebreast carcinomatype 2 diabetes mellitusdiabetes mellitus
✦AI Summary

Based on the provided abstracts, there appears to be confusion between two different protein complexes both abbreviated as PRC1. The abstracts primarily discuss Polycomb Repressive Complex 1 (PRC1), a chr15-regulating complex involved in gene silencing, rather than the cytokinesis regulator specified in the gene description. Polycomb PRC1 functions as a histone H2A E3 ubiquitin ligase that catalyzes monoubiquitylation of histone H2A at lysine 119 (H2AK119Ub) 1. This complex maintains gene silencing by compacting chr15 and works in conjunction with PRC2, which methylates histone H3 at lysine 27 2. PRC1 demonstrates a read-write mechanism where it recognizes existing H2AK119Ub modifications and establishes new ones through asymmetrical nucleosome binding 3. In hematopoiesis, PRC1 complexes maintain cell identity during differentiation and are frequently mutated in hematological malignancies 4. The complex also plays roles in cancer progression, driving metastasis in prostate cancer by coordinating stemness with immune suppression 5, and has been identified as a potential biomarker in hepatocellular carcinoma 6. Additionally, RING1, a PRC1 component, regulates inflammatory responses by promoting GSDMD degradation 7. However, insufficient information is provided about the cytokinesis-specific PRC1 protein mentioned in the gene description.

Sources cited
1
PRC1 compacts chromatin and catalyzes monoubiquitylation of histone H2A
PMID: 21248841
2
PRC1 works with PRC2 which methylates histone H3 at lysine 27
PMID: 12351676
3
PRC1 demonstrates read-write mechanism through asymmetrical nucleosome binding
PMID: 39537923
4
PRC1 maintains cell identity during hematopoiesis and is mutated in blood cancers
PMID: 28087428
5
PRC1 drives metastasis by coordinating stemness with immune suppression
PMID: 31327655
6
PRC1 identified as potential biomarker in hepatocellular carcinoma
PMID: 40169794
7
RING1 component regulates inflammatory responses via GSDMD degradation
PMID: 40369166
Disease Associationsⓘ20
neurodegenerative diseaseOpen Targets
0.51Moderate
breast carcinomaOpen Targets
0.50Moderate
type 2 diabetes mellitusOpen Targets
0.49Moderate
diabetes mellitusOpen Targets
0.45Moderate
breast cancerOpen Targets
0.43Moderate
estrogen-receptor positive breast cancerOpen Targets
0.42Moderate
diabetic neuropathyOpen Targets
0.36Weak
lysosomal storage diseaseOpen Targets
0.31Weak
migraine disorderOpen Targets
0.30Weak
high grade ovarian serous adenocarcinomaOpen Targets
0.27Weak
ovarian carcinomaOpen Targets
0.26Weak
luminal B breast carcinomaOpen Targets
0.25Weak
diabetic eye diseaseOpen Targets
0.25Weak
prostate carcinomaOpen Targets
0.25Weak
diabetic retinopathyOpen Targets
0.24Weak
schizophreniaOpen Targets
0.23Weak
HER2 negative breast carcinomaOpen Targets
0.21Weak
ovarian neoplasmOpen Targets
0.19Weak
Hereditary breast cancerOpen Targets
0.18Weak
hereditary breast carcinomaOpen Targets
0.18Weak
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
TUBA1BProtein interaction100%CITProtein interaction99%PTTG1Protein interaction97%KIF18AProtein interaction95%NDC80Protein interaction93%TUBB2BProtein interaction92%
Tissue Expression6 tissues
Brain
100%
Ovary
9%
Lung
9%
Bone Marrow
8%
Liver
3%
Heart
1%
Gene Interaction Network
Click a node to explore
PRC1TUBA1BCITPTTG1KIF18ANDC80TUBB2B
PROTEIN STRUCTURE
Preparing viewer…
PDB3NRX · 1.75 Å · X-ray
View on RCSB ↗
Constraintⓘ
LOEUFⓘ
0.70LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF0.56 [0.45–0.70]
RankingsWhere PRC1 stands among ~20K protein-coding genes
  • #2,448of 20,598
    Most Researched178 · top quartile
  • #5,383of 17,882
    Most Constrained (LOEUF)0.70
Genes detectedPRC1
Sources retrieved26 papers
Response time—
📄 Sources
26▼
1
The Polycomb complex PRC2 and its mark in life.
PMID: 21248841
Nature · 2011
1.00
2
Role of histone H3 lysine 27 methylation in Polycomb-group silencing.
PMID: 12351676
Science · 2002
0.90
3
Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stability.
PMID: 37735617
Nat Struct Mol Biol · 2023
0.80
4
Targeted disruption of PRC1.1 complex enhances bone remodeling.
PMID: 40341537
Nat Commun · 2025
0.76
5
The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression.
PMID: 31327655
Cancer Cell · 2019
0.70