PRCP (prolylcarboxypeptidase) is a serine protease that cleaves C-terminal amino acids linked to proline residues in peptide substrates, including angiotensin II, angiotensin III, and des-Arg9-bradykinin 1. The enzyme functions primarily in lysosomes but retains enzymatic activity extracellularly after release 1. PRCP operates across multiple physiological pathways including the renin-angiotensin system (RAS), kallikrein-kinin system (KKS), and pro-opiomelanocortin (POMC) system 2. The enzyme exhibits cardioprotective properties by regulating vascular tone and angiotensin molecules, modulating endothelial cell migration and angiogenesis 3. PRCP expression is regulated by glucocorticoids and opioid receptor agonists 3. Genetically, PRCP polymorphisms associate with essential hypertension, with rs3750931 G allele carriers showing elevated blood pressure 4. Recent Mendelian randomization studies identify elevated PRCP gene expression in blood as causally associated with decreased intracranial aneurysm rupture risk 56. PRCP represents a promising therapeutic target for cardiovascular, inflammatory, and metabolic diseases, though additional characterization of signaling pathway complexity is required to fully realize its therapeutic potential 2.