PRKCA encodes protein kinase C alpha, a calcium-activated serine/threonine kinase that regulates diverse cellular processes through phosphorylation of downstream targets. The protein plays critical roles in immune cell function, particularly in eosinophils where it mediates EET-induced neuroendocrine cell activation via the CCDC25-ILK-PKCα-CRTC1 pathway, contributing to asthma progression 1. PRKCA exhibits disease-relevant genetic variation, with polymorphisms affecting antihypertensive drug responses through gene-gene interactions with NOS3 and BDKRB2 2. The gene shows pleiotropic associations, being linked to both body mass index and asthma susceptibility through specific SNP variants 3. In cancer biology, PKCα demonstrates tissue-specific dependencies, with mutant EGFR lung adenocarcinomas showing particular reliance on PKCα for anchorage-independent growth and survival 4. Epigenetic regulation of PRKCA involves DNA methylation and antisense lncRNA PRKCA-AS1, which coordinates DNMT1 recruitment to control transcription in rheumatic heart disease 5. Additionally, PRKCA expression and alternative splicing are functionally linked to multiple sclerosis susceptibility, with protective variants associated with higher expression levels and altered exon inclusion patterns 6. The protein also mediates heregulin-induced apoptosis through caspase activation pathways 7.