PRKCE encodes protein kinase C epsilon (PKCε), a calcium-independent, diacylglycerol-dependent serine/threonine kinase with pleiotropic functions across multiple cell types 1. In cardiac myocytes, PKCε regulates myofilament function and excitation-contraction coupling at sarcomeres, and modulates cardiac energy production via mitochondrial targeting 1. PKCε mediates cell adhesion, migration, and cytoskeletal rearrangement through phosphorylation of cytoskeletal and adhesion proteins, including MARCKS, vimentin, keratin-8, and IQGAP1 1. During cytokinesis, PKCε facilitates daughter cell separation through interaction with YWHAB 1. In cancer biology, PKCε plays context-dependent roles. In kidney renal clear cell carcinoma, low PRKCE expression associates with poor survival, higher tumor grades, and immune infiltration patterns, suggesting tumor-suppressive functions 2. Conversely, in prostate cancer, PKCε phosphorylates STAT3 to enhance cancer cell invasion 1. PKCε also regulates apoptosis; IPS-1 signaling downregulates anti-apoptotic PRKCE expression in cancer cells 3. In immune and metabolic contexts, PRKCE mutations cause genetic insulin resistance syndrome 4, PRKCE shows altered methylation in nonalcoholic fatty liver disease 5, and myeloid PKCε functions as atheroprotective by restricting macrophage lipid uptake 6. Additionally, PKCε mediates nociceptor sensitization and pain plasticity 7. Genetic variants in PRKCE, concentrated in the hinge and C-terminal regions, influence protein dynamics and disease associations 8.