PRRC2B (Proline-Rich Coiled-Coil 2B) is an RNA-binding protein that functions as a regulator of translation initiation and mRNA stability. Mechanistically, PRRC2B binds to CU- or GA-rich sequences near translation initiation codons on specific mRNAs 1 and interacts with eukaryotic translation initiation factors eIF3 and eIF4G2 to promote efficient translation of cell cycle regulators like CCND2 1. Additionally, PRRC2B promotes leaky scanning past upstream open reading frames (uORFs), facilitating translation of mRNAs containing these regulatory elements 2. The long isoform of PRRC2B also binds 5' TOP mRNAs and preserves their stability during amino acid starvation, maintaining ribosomal protein translation capacity for post-starvation recovery 3. Disease relevance includes associations with cancer pathways and developmental malignancies; PRRC2B expression correlates with poor survival in Wilms' tumor 4 and participates in ALK-rearranged mesenchymal neoplasms through gene fusion 5. Clinically, PRRC2B is emerging as a potential diagnostic and therapeutic target in chr9 obstructive pulmonary disease through competitive endogenous RNA regulatory networks 6, and shows proteomic significance in preeclampsia pathophysiology 7.