RAB2B is a small GTPase belonging to the Rab family that regulates intracellular membrane trafficking and organelle homeostasis. As a GTP-binding protein, RAB2B cycles between active GTP-bound and inactive GDP-bound states to control vesicular transport 1. RAB2B localizes to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) and cis-Golgi, where it non-redundantly regulates Golgi morphology through interaction with the specific effector protein GARI-L4 2. RAB2B functions in multiple pathways: it stimulates LC3 lipidation on Golgi membranes through a non-canonical autophagy mechanism 3, activates ERK signaling at the ERGIC-Golgi interface 4, and promotes cytosolic DNA-induced innate immune responses by regulating the cGAS-STING signaling axis alongside its effector GARIL5 5. RAB2B overexpression occurs in multiple human cancers including colon adenocarcinoma 1 and is implicated in cancer progression. MicroRNA-mediated RAB2B suppression (via miR-425 and miR-448) induces apoptosis and inhibits proliferation, migration, and invasion in cervical and pancreatic cancer cells 67. Elevated plasma RAB2B levels serve as a diagnostic biomarker for pancreatic cancer when combined with other proteins 8.