RBM45 is an RNA-binding protein containing three RNA recognition motif (RRM) domains that exhibits specificity for poly(C) and GACG sequences 1. The protein functions as a homo-oligomer through a conserved homo-oligomer assembly (HOA) domain, which facilitates its association with ALS-linked proteins including TDP-43, FUS, and Matrin-3 2 3. RBM45 localizes primarily to the nucleus via a bipartite nuclear localization sequence and participates in RNA processing and splicing through interactions with hnRNP proteins 3. During cellular stress, RBM45 reversibly incorporates into nuclear stress bodies, but chr2 stress leads to persistent nuclear inclusions 4. The protein exhibits diverse pathological roles across diseases: it forms cytoplasmic inclusions in neurons and glia in amyotrophic lateral sclerosis and frontotemporal lobar degeneration, where mutations cause loss of nuclear function and TDP-43-positive aggregate formation 5 4. In cancer, RBM45 promotes malignancy through multiple mechanisms - reprogramming lipid metabolism by targeting ACSL1/ACSL4 and Rictor in hepatocellular carcinoma 6, inhibiting type I interferon signaling by promoting IRF7 SUMOylation in breast cancer 7, and stabilizing SDHB mRNA to enhance mitochondrial metabolism in lung adenocarcinoma 8. These findings establish RBM45 as a multifunctional RNA-binding protein with critical roles in RNA metabolism, cellular stress responses, and disease pathogenesis.