RBM6 (RNA binding motif protein 6) is an RNA-binding protein with primary function in alternative splicing regulation and RNA processing. It specifically binds poly(G) RNA homopolymers and interacts with mRNAs containing GGCGAUG and CUCU binding motifs 1. RBM6 regulates alternative splicing of genes involved in DNA damage response, apoptosis, and cell proliferation pathways 1. The protein localizes to the nucleus where it coordinates mRNA splicing via spliceosome machinery 2. RBM6 demonstrates tumor-suppressor activity across multiple cancer types. In laryngocarcinoma, RBM6 overexpression suppresses cell proliferation and invasion while promoting apoptosis through EGFR-ERK pathway inhibition 3. In HeLa cells, RBM6 knockdown promotes proliferation and inhibits apoptosis, confirming its anti-oncogenic role 1. However, in prostate cancer, RBM6's function is context-dependent: it enhances migration under normal conditions but inhibits migration when ZEB1 is highly expressed 4. Clinically, RBM6 represents a pleiotropic gene connecting psychiatric and metabolic disorders 5, and emerges as a shared susceptibility gene between gastroesophageal reflux disease and asthma 6. RBM6 alterations occur in rhabdomyosarcoma through novel gene fusions 7. Higher RBM6 expression associates with better prognosis across many cancer types 1, suggesting therapeutic potential as a tumor-suppressor target.