RECQL is a nuclear DNA helicase that plays a critical role in maintaining genome stability through multiple DNA repair pathways 1. The protein exhibits Mg2+-dependent ATP-driven helicase activity that unwinds DNA in the 3'-5' direction, processes forked DNA substrates, resolves Holliday junctions, and possesses DNA strand annealing activity 1. RECQL is essential for restarting stalled replication forks caused by topoisomerase lesions and restoring regressed replication forks, contributing to resistance against ultraviolet-induced and mutagen-induced DNA damage 1. Functionally, RECQL deficiency results in reduced genomic stability and increased tumor mutation burden in cancer cells 2. Clinically, RECQL mutations associate with moderate breast cancer risk, particularly in African American populations, with some studies identifying founder mutations in French-Canadian and Polish cohorts 3. However, evidence for increased breast cancer susceptibility remains conflicting across populations, with some case-control studies failing to confirm elevated risk 4. RECQL loss appears as an early event in breast cancer development, correlating with aggressive pathology, increased immune infiltration, and poor survival outcomes 2. While RECQL mutations are detected in colorectal cancer families and proposed as a susceptibility factor in Chinese breast cancer populations, current evidence is insufficient to routinely include RECQL on clinical cancer gene panels 4.