RENBP (renin binding protein) is an X-chromosome X enzyme that catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine, functioning as N-acylglucosamine 2-epimerase 123. It participates in the degradation pathway of N-glycolylneuraminic acid (Neu5Gc), a sialic acid present in food that humans cannot synthesize due to an inactive CMAH enzyme 3. RENBP is involved in regulating blood pressure and functions as an endopeptidase inhibitor 4. Genetically, RENBP variants have been associated with psychiatric disorders. A genome-wide association study identified SNP rs2269372 in RENBP at genome-wide significance for schizophrenia susceptibility in Han Chinese populations (P=3.98×10⁻⁸) 5. Systematic review of GWAS studies confirmed RENBP as a schizophrenia-associated locus 6. However, RENBP polymorphisms showed no direct association with essential hypertension in large-scale GWAS analyses 7. Recent studies reveal RENBP's clinical relevance in cancer immunotherapy and inflammatory disease. RENBP emerged as a prognostic biomarker in laryngeal cancer, with high-risk RENBP expression correlating with reduced CD8+ T cell infiltration and altered immunotherapy response 8. RENBP inhibition enhances metabolic glycoengineering efficiency in antigen-presenting cells, with 1.2-1.4 fold increases in vitro and >3-fold enhancement in B cells in vivo 4. Additionally, RENBP expression correlates with bronchopulmonary dysplasia severity in preterm infants 9.