RSRC1 (arginine and serine rich coiled-coil 1) is a ubiquitously expressed nuclear protein with primary functions in alternative splicing and transcription regulation 1. The protein contains arginine and serine-rich domains characteristic of splicing regulatory factors and likely participates in 3' splice site recognition during the second catalytic step of pre-mRNA splicing 1. RSRC1 functions through protein-protein interactions, including SUMO-mediated modifications that enhance estrogen receptor β SUMOylation 2. Mutations in RSRC1 cause autosomal recessive intellectual developmental disorder with aberrant behavior, hypotonia, and mild facial dysmorphism 1. Loss-of-function triggers nonsense-mediated decay and disrupts splicing of genes associated with intellectual disability and schizophrenia, particularly downregulating IGFBP3, whose deficiency correlates with behavioral and synaptic dysfunction 1. Genetic variants in RSRC1 are associated with increased schizophrenia risk through altered dorsolateral prefrontal cortex activation during cognitive tasks 34, and with major depressive disorder susceptibility 5. Additionally, RSRC1 rs6441201 polymorphisms associate with neuroblastoma susceptibility in Chinese populations 6, while RSRC1 expression suppresses gastric cancer cell proliferation by regulating PTEN tumor suppressor expression 7. Recent evidence suggests RSRC1 has evolutionarily conserved, causal roles in aging processes 8.