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10 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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RTP4
receptor transporter protein 4
Chromosome 3 · 3q27.3
NCBI Gene: 64108Ensembl: ENSG00000136514.3HGNC: HGNC:23992UniProt: Q96DX8
15PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingprotein targeting to membranedefense response to viruscytoplasmhemiplegiaosteoarthritis, hipliver diseaseovarian neoplasm
✦AI Summary

RTP4 (receptor transporter protein 4) functions as a dual-role Golgi chaperone with distinct roles in receptor trafficking and antiviral immunity. As a chaperone protein, RTP4 facilitates cell surface expression of G-protein coupled receptors, including the bitter taste receptor TAS2R16 1. However, RTP4's primary characterized function involves potent antiviral activity. As an interferon-stimulated gene (ISG), RTP4 restricts replication of multiple RNA viruses including influenza A, West Nile virus, yellow fever virus, and flaviviruses 23. For influenza A specifically, RTP4 directly targets the viral NS1 protein in an RNA-dependent manner, sequestering it from the TRIM25-RIG-I complex and restoring antiviral signaling through IRF3 activation 4. However, RTP4 demonstrates context-dependent immunoregulation: while enhancing antiviral responses in most tissues, it negatively regulates TBK1 signaling in the brain, suppressing type I interferon responses and exacerbating cerebral malaria pathology 5. Clinically, RTP4 genetic variants associate with fatigue severity in primary Sjögren's syndrome patients, correlating with type I interferon activity 6. These findings reveal RTP4 as a critical but pleiotropic regulator of both receptor biology and antiviral immunity with tissue-specific functions.

Sources cited
1
RTP4 promotes functional expression of the bitter taste receptor TAS2R16
PMID: 16720576
2
RTP4 is an ISG with targeted antiviral activity against multiple viruses including yellow fever virus
PMID: 21478870
3
RTP4 restricts influenza A virus by targeting NS1 protein and restoring TRIM25-RIG-I-mediated antiviral signaling
PMID: 39798334
4
RTP4 is among the strongest ISG hits for inhibiting flavivirus replication including West Nile virus
PMID: 40112111
5
RTP4 negatively regulates TBK1 signaling and inhibits type I IFN response in brain tissue during malaria infection
PMID: 32709745
6
RTP4 genetic variants associate with fatigue in primary Sjögren's syndrome and RTP4 expression correlates with type I interferon score
PMID: 34907023
Disease Associationsⓘ20
hemiplegiaOpen Targets
0.33Weak
osteoarthritis, hipOpen Targets
0.26Weak
liver diseaseOpen Targets
0.13Weak
ovarian neoplasmOpen Targets
0.13Weak
type 2 diabetes mellitusOpen Targets
0.08Suggestive
attention deficit hyperactivity disorderOpen Targets
0.07Suggestive
hereditary attention deficit-hyperactivity disorderOpen Targets
0.06Suggestive
attention deficit-hyperactivity disorder 8Open Targets
0.05Suggestive
intellectual disability, autosomal recessive 59Open Targets
0.05Suggestive
schizophrenia 15Open Targets
0.05Suggestive
Tourette syndromeOpen Targets
0.05Suggestive
corneal neovascularizationOpen Targets
0.05Suggestive
autismOpen Targets
0.05Suggestive
glomerulonephritisOpen Targets
0.04Suggestive
ectropionOpen Targets
0.04Suggestive
entropionOpen Targets
0.04Suggestive
ThrombocytopeniaOpen Targets
0.04Suggestive
drug allergyOpen Targets
0.04Suggestive
sweat gland diseaseOpen Targets
0.04Suggestive
Phelan-McDermid syndromeOpen Targets
0.04Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
RSAD2Protein interaction95%IFIT1Protein interaction95%IRF7Protein interaction94%IFIT3Protein interaction92%MX1Protein interaction92%MX2Protein interaction92%
Tissue Expression6 tissues
Liver
100%
Heart
83%
Lung
72%
Bone Marrow
46%
Ovary
43%
Brain
20%
Gene Interaction Network
Click a node to explore
RTP4RSAD2IFIT1IRF7IFIT3MX1MX2
PROTEIN STRUCTURE
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AlphaFoldAI-predicted · UniProt Q96DX8
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
1.17LoF Tolerant
pLIⓘ
0.23Tolerant
Observed/Expected LoF0.46 [0.21–1.17]
RankingsWhere RTP4 stands among ~20K protein-coding genes
  • #15,679of 20,598
    Most Researched15
  • #12,279of 17,882
    Most Constrained (LOEUF)1.17
Genes detectedRTP4
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens.
PMID: 30343902
Cell · 2018
1.00
2
A diverse range of gene products are effectors of the type I interferon antiviral response.
PMID: 21478870
Nature · 2011
0.90
3
FGF10 attenuates allergic airway inflammation in asthma by inhibiting PI3K/AKT/NF-κB pathway.
PMID: 37956773
Cell Signal · 2024
0.80
4
MITD1 is a brain-specific interferon-inducible factor that inhibits flavivirus replication.
PMID: 40112111
Proc Natl Acad Sci U S A · 2025
0.70
5
RTP4 restricts influenza A virus infection by targeting the viral NS1 protein.
PMID: 39798334
Virology · 2025
0.60