SBNO1 (strawberry notch homolog 1) is a nuclear protein critical for neural development and neuronal genome stability. During cortical development, SBNO1 is highly expressed in the cortical plate with developmental regulation persisting into postnatal stages 1. SBNO1 promotes neural stem cell proliferation through the PI3K-Akt/GSK3B/Wnt-β-catenin signaling axis and enhances secretion of small extracellular vesicles that suppress neuroinflammation by inhibiting MAPK and NF-κB pathways in microglia [UniProt]. At the molecular level, SBNO1 safeguards neuronal genome integrity by regulating YEATS4 expression; SBNO1 knockout increases genomic DNA damage and apoptosis in cortical neurons, which YEATS4 overexpression can rescue 2. SBNO1 is essential for normal neurite outgrowth—CRISPR-based knockout in cultured neurons causes delayed neurite growth, while cortical neuron-specific knockout mice show hypotrophy of axon bundles and dendrites 3. Mutations in SBNO1 are associated with neurodevelopmental disorders including schizophrenia and intellectual disability 43. Notably, SBNO1 variants show genetic-epigenetic interactions with antipsychotic drug treatment response in schizophrenia patients, supporting precision medicine approaches 5. SBNO1 expression is also altered in glioblastoma and identified as a potential biomarker in idiopathic pulmonary fibrosis 67.