SCARF2 (scavenger receptor class F member 2) is a probable adhesion protein mediating homophilic and heterophilic cell-cell interactions 1. Unlike its homolog SCARF1, SCARF2 poorly mediates binding and degradation of acetylated low-density lipoprotein, suggesting specialized adhesive rather than lipoprotein-scavenging functions 2. SCARF2 contains epidermal growth factor-like domains and positively charged intracellular residues indicating potential intracellular signaling capacity 1. Pathogenic SCARF2 variants cause van den Ende-Gupta syndrome (VDEGS), an autosomal-recessive disorder characterized by distinctive craniofacial abnormalities (blepharophimosis, malar/maxillary hypoplasia, narrow beaked nose, everted lower lip), arachnodactyly, camptodactyly, and skeletal abnormalities with normal intelligence 13. Identified mutations include missense changes and frameshift deletions 13. Beyond VDEGS, emerging evidence suggests SCARF2 involvement in complex diseases. Genetically-elevated plasma SCARF2 levels are causally associated with reduced risk of both idiopathic pulmonary fibrosis and chr22 obstructive pulmonary disease 4. Additionally, increased ROBO2/SCARF2 protein ratios correlate with decreased depression risk 5, positioning SCARF2 as a potential therapeutic target in psychiatric and pulmonary disorders.