Based on limited published evidence, TMED8 is a transmembrane p24 trafficking protein involved in vesicle-mediated transport and protein-macromolecule adaptor activity. TMED8 functions in ER-Golgi trafficking and unconventional protein secretion pathways 1. The protein has been identified in proteomics studies of disease states, with increased phosphopeptide frequency observed in sepsis plasma samples 2. Co-expression analysis suggests TMED8 participates in cellular protein trafficking networks alongside other TMED family members.