YIPF1 (Yip1 domain family member 1) is a trans-Golgi-localizing protein that plays critical roles in Golgi architecture and function. YIPF1 primarily localizes to the medial-/trans-Golgi and trans-Golgi network (TGN) 1, featuring a cytosol-oriented N-terminal region followed by five transmembrane domains and a lumen-oriented C-terminus 2. YIPF1 forms stable protein complexes with YIPF6, which is essential for proper expression and localization of both proteins 1. Functionally, YIPF1 regulates membrane dynamics within the endomembrane system 2 and is critical for Golgi apparatus reassembly following pharmacological disruption, as YIPF1 knockdown significantly delays post-brefeldin A recovery 1. Additionally, YIPF1 supports normal intracellular glycan synthesis 1. Beyond basic cellular function, YIPF1 has emerged as a disease biomarker: it was identified as associated with angiotensin II receptor blocker (ARB) response in hypertension pharmacogenomics 3, and was incorporated into a prognostic model for hepatocellular carcinoma with microvascular invasion 4. YIPF1 also appears as a hub gene in glioblastoma multiforme molecular networks 5. These findings suggest YIPF1 coordinates essential secretory pathway functions with potential roles in disease pathogenesis.