LDLRAD1 — low density lipoprotein receptor class A domain containing 1

11 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

8PubMed Papers

#17,707 · top 91% of 19K genes

20Diseases

top 87%

0Drugs

0Pathogenic Variants

ReceptorExperimental GO EvidenceSwiss-Prot Reviewed

protein bindingvesicle-mediated transportmembraneankylosing spondylitisbenign neoplasmhypoparathyroidism, familial isolated, 2pseudohypoparathyroidism type 2

AI Summary

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low density lipoprotein receptor class A domain containing 1

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations20

ankylosing spondylitisOpen Targets

0.28Weak

benign neoplasmOpen Targets

0.19Weak

hypoparathyroidism, familial isolated, 2Open Targets

0.04Suggestive

pseudohypoparathyroidism type 2Open Targets

0.04Suggestive

congenital enteropathy due to enteropeptidase deficiencyOpen Targets

0.04Suggestive

Familial isolated hypoparathyroidismOpen Targets

0.04Suggestive

congenital lethal erythrodermaOpen Targets

0.04Suggestive

intestinal hypomagnesemia 1Open Targets

0.04Suggestive

Primary hypomagnesemia with secondary hypocalcemiaOpen Targets

0.04Suggestive

gastric mucosal hypertrophyOpen Targets

0.04Suggestive

pseudohyperaldosteronism type 2Open Targets

0.04Suggestive

Rotor syndromeOpen Targets

0.04Suggestive

Liddle syndrome 2Open Targets

0.03Suggestive

Liddle syndrome 3Open Targets

0.03Suggestive

22q11.2 deletion syndromeOpen Targets

0.03Suggestive

nephrotic syndrome 15Open Targets

0.03Suggestive

familial isolated hypoparathyroidism due to agenesis of parathyroid glandOpen Targets

0.03Suggestive

ulna metaphyseal dysplasia syndromeOpen Targets

0.03Suggestive

Liddle syndrome 1Open Targets

0.03Suggestive

Deafness - small bowel diverticulosis - neuropathyOpen Targets

0.03Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression6 tissues

Lung

100%

Brain

Liver

Bone Marrow

Ovary

Heart

Gene Interaction Network6 neighbors

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StructureAlphaFold

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AlphaFoldAI-predicted · UniProt Q5T700

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ConstraintgnomAD v4.1

LOEUFⓘ

1.14LoF Tolerant

pLIⓘ

0.00Tolerant

Observed/Expected LoF0.79 [0.56–1.14]

Rankings2 dim

Where LDLRAD1 stands among ~20K protein-coding genes

#17,636of 20,598
Most Researched8
#11,868of 17,882
Most Constrained (LOEUF)1.14